Ensiklopedia Dunia

Xilazina
Data klinis
Pengucapan	/ˈzaɪləziːn/; ZY-lə-zeen
Nama dagang	Rompun, Anased, Sedazine, Chanazine, dll
AHFS/Drugs.com	International Drug Names
License data	US DailyMed: Xylazine;
Rute; pemberian	Oral, inhalasi, subkutan, intra otot, infus
Kode ATCvet	QN05CM92 (WHO) ;
Status hukum
Status hukum	AU: S4 (Prescription only) ; UK: Kelas C ; US: ℞-only ; Penggunaan Veteriner;
Pengenal
	Nama IUPAC N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine;
Nomor CAS	7361–61–7 ;
PubChem CID	5707;
IUPHAR/BPS	523;
ChemSpider	5505 ;
UNII	2KFG9TP5V8;
KEGG	D08683 ;
ChEMBL	ChEMBL297362 ;
CompTox Dashboard (EPA)	DTXSID3040643 ;
ECHA InfoCard	100.028.093
Data sifat kimia dan fisik
Rumus	C12H16N2S
Massa molar	220,33 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
	SMILES N\1=C(\SCCC/1)Nc2c(cccc2C)C;
	InChI InChI=1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14) ; Key:BPICBUSOMSTKRF-UHFFFAOYSA-N ;
	(what is this?) (verify)

Xilazina adalah analog struktural dari klonidin serta merupakan agonis reseptor adrenergik α2.^[1] Senyawa ini dipasarkan dengan berbagai nama dagang di seluruh dunia, terutama dengan merek Rompun yang diproduksi oleh Bayer,^[2] serta dengan nama Anased, Sedazine, dan Chanazine.^[3]

Xylazine merupakan obat veteriner yang umum digunakan untuk keperluan sedasi, anestesi, relaksasi otot, serta analgesia pada hewan seperti kuda, sapi, dan mamalia lainnya.^[2] Dalam praktik anestesi veteriner, senyawa ini sering dipakai bersama ketamin. Selain itu, dokter hewan juga memanfaatkan xylazine sebagai emetik, khususnya pada kucing. Interaksi farmakologisnya bervariasi bergantung pada spesies hewan yang diberi perlakuan.^[4]^[5]^[6]

Referensi

^ Greene SA, Thurmon JC (December 1988). "Xylazine–a review of its pharmacology and use in veterinary medicine". Journal of Veterinary Pharmacology and Therapeutics. 11 (4): 295–313. doi:10.1111/j.1365-2885.1988.tb00189.x. PMID 3062194.
^ ^a ^b "Xylazine". drugs.com.
^ Ruiz-Colón K, Chavez-Arias C, Díaz-Alcalá JE, Martínez MA (July 2014). "Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: A comprehensive review of the literature". Forensic Science International. 240: 1–8. doi:10.1016/j.forsciint.2014.03.015. PMID 24769343.
^ Haskins SC, Patz JD, Farver TB (March 1986). "Xylazine and xylazine-ketamine in dogs". American Journal of Veterinary Research. 47 (3): 636–641. doi:10.2460/ajvr.1986.47.03.636. PMID 3963565.
^ Muir WW, Skarda RT, Milne DW (February 1977). "Evaluation of xylazine and ketamine hydrochloride for anesthesia in horses". American Journal of Veterinary Research. 38 (2): 195–201. doi:10.2460/ajvr.1977.38.02.195. PMID 842917.
^ Aithal HP, Pratap AK, Singh GR (1997). "Clinical effects of epidurally administered ketamine and xylazine in goats". Small Ruminant Research. 24 (1): 55–64. doi:10.1016/s0921-4488(96)00919-4.

Bacaan lebih lanjut

McCurnin DM, Bassert JM (2002). Clinical Textbook for Veterinary Technicians (Edisi 5th). Philadelphia: Saunders.
"Rompun Homepage". Bayer Healthcare. 2005. Diarsipkan dari asli tanggal 2007-03-02. Diakses tanggal 2016-07-21.
Wright B (2000). "Human health concerns when working with medications around horses". Agdex# 460. Ontario Ministry of Agriculture, Food and Rural Affairs (OMAFRA). Diarsipkan dari asli tanggal 7 September 2006.

Pranala luar

"Xylazine". National Institute on Drug Abuse (NIDA). 21 April 2022. Diarsipkan dari asli tanggal June 6, 2022.

Artikel bertopik kimia ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[Greene_1988-1] Greene SA, Thurmon JC (December 1988). "Xylazine–a review of its pharmacology and use in veterinary medicine". Journal of Veterinary Pharmacology and Therapeutics. 11 (4): 295–313. doi:10.1111/j.1365-2885.1988.tb00189.x. PMID 3062194.

[Xylazine-2] "Xylazine". drugs.com.

[RuizColon_2014-3] Ruiz-Colón K, Chavez-Arias C, Díaz-Alcalá JE, Martínez MA (July 2014). "Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: A comprehensive review of the literature". Forensic Science International. 240: 1–8. doi:10.1016/j.forsciint.2014.03.015. PMID 24769343.

[Haskins_1986-4] Haskins SC, Patz JD, Farver TB (March 1986). "Xylazine and xylazine-ketamine in dogs". American Journal of Veterinary Research. 47 (3): 636–641. doi:10.2460/ajvr.1986.47.03.636. PMID 3963565.

[Muir_1977-5] Muir WW, Skarda RT, Milne DW (February 1977). "Evaluation of xylazine and ketamine hydrochloride for anesthesia in horses". American Journal of Veterinary Research. 38 (2): 195–201. doi:10.2460/ajvr.1977.38.02.195. PMID 842917.

[Aithal_1997-6] Aithal HP, Pratap AK, Singh GR (1997). "Clinical effects of epidurally administered ketamine and xylazine in goats". Small Ruminant Research. 24 (1): 55–64. doi:10.1016/s0921-4488(96)00919-4.

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[5]

[6]

Ensiklopedia Dunia

Xilazina

Referensi

Bacaan lebih lanjut

Pranala luar

Beranda

Program Studi

Data klinis


Pengucapan	/ˈzaɪləziːn/ ZY-lə-zeen
Nama dagang	Rompun, Anased, Sedazine, Chanazine, dll
AHFS/Drugs.com	International Drug Names
License data	US DailyMed: Xylazine
Rute pemberian	Oral, inhalasi, subkutan, intra otot, infus
Kode ATCvet	QN05CM92 (WHO)
Status hukum
Status hukum	AU: S4 (Prescription only) UK: Kelas C US: ℞-only Penggunaan Veteriner
Pengenal
Nama IUPAC N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
Nomor CAS	7361–61–7^Y
PubChem CID	5707
IUPHAR/BPS	523
ChemSpider	5505^Y
UNII	2KFG9TP5V8
KEGG	D08683^Y
ChEMBL	ChEMBL297362^Y
CompTox Dashboard (EPA)	DTXSID3040643
ECHA InfoCard	100.028.093
Data sifat kimia dan fisik
Rumus	C₁₂H₁₆N₂S
Massa molar	220,33 g·mol⁻¹
Model 3D (JSmol)	Gambar interaktif
SMILES N\1=C(\SCCC/1)Nc2c(cccc2C)C
InChI InChI=1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)^N Key:BPICBUSOMSTKRF-UHFFFAOYSA-N^N
^NY (what is this?) (verify)