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Interleukin-18
Struktur yang tersedia
PDB	Pencarian ortolog: PDBe RCSB
Daftar kode ID PDB
	1J0S, 2VXT, 3F62, 4EEE, 4EKX, 4HJJ, 3WO2, 3WO3, 3WO4, 4R6U, 4XFS, 4XFT, 4XFU
Pengidentifikasi
Alias	IL18, IGIF, IL-18, IL-1g, IL1F4, interleukin 18
ID Eksternal	OMIM: 600953; MGI: 107936; HomoloGene: 1200; GeneCards: IL18; OMA:IL18 - orthologs
Pola ekspresi RNA
	Ekspresi tertinggi di
	skin of abdomen; ; skin of leg; ; rektum; ; skin of thigh; ; kantung empedu; ; mucosa of transverse colon; ; olfactory zone of nasal mucosa; ; germinal epithelium; ; penis manusia; ; rongga mulut;
	Ekspresi tertinggi di
	epithelium of stomach; ; pyloric antrum; ; mucous cell of stomach; ; left colon; ; skin of external ear; ; Kerongkongan; ; Usus dua belas jari; ; Usus kosong; ; limpa; ; bibir;
	Referensi data ekspresi selengkapnya
	Data ekspresi referensi lebih lanjut
Ontologi gen
Fungsi molekuler	Ikatan protein plasma; cytokine activity; interleukin-18 receptor binding;
Komponen seluler	sitosol; extracellular region; extracellular space;
Proses biologis	positive regulation of inflammatory response; cell-cell signaling; cellular response to organic cyclic compound; type 2 immune response; MAPK cascade; positive regulation of natural killer cell proliferation; Tidur; regulation of cell adhesion; positive regulation of NK T cell proliferation; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of tissue remodeling; Angiogenesis; T-helper 1 type immune response; positive regulation of interleukin-17 production; inflammatory response; lipopolysaccharide-mediated signaling pathway; positive regulation of activated T cell proliferation; positive regulation of protein kinase B signaling; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of smooth muscle cell proliferation; activation of protein kinase B activity; positive regulation of transcription by RNA polymerase II; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of gene expression; positive regulation of macrophage derived foam cell differentiation; natural killer cell activation; positive regulation of interferon-gamma production; cholesterol homeostasis; positive regulation of T-helper 2 cell differentiation; negative regulation of myoblast differentiation; triglyceride homeostasis; cell population proliferation; regulation of signaling receptor activity; interleukin-6 production; T-helper 1 cell cytokine production; neutrophil activation; natural killer cell mediated cytotoxicity; cytokine-mediated signaling pathway; interleukin-18-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; respons imun; positive regulation of NF-kappaB transcription factor activity; positive regulation of T-helper 1 cell cytokine production; positive regulation of cold-induced thermogenesis; positive regulation of neuroinflammatory response; signal transduction;
	Sumber:Amigo / QuickGO
Ortologi
	3606
	16173
	ENSG00000150782
	ENSMUSG00000039217
	Q14116
	P70380
	NM_001243211; NM_001562; NM_001386420
	NM_008360; NM_001357221; NM_001357222
	NP_001230140; NP_001553; NP_001230140.1
	NP_032386; NP_001344150; NP_001344151
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Interleukin-18 (bahasa Inggris: interleukin-18, interferon-gamma-inducing factor, IL-18code: en is deprecated ) adalah sitokina yang merupakan ekspresi genetik IL18,^[3] dengan prekursor sepanjang 192 AA dan protein aktif sepanjang 157 AA yang meningkatkan respon peradangan tubuh dengan menginduksi sekresi interferon-gamma oleh sel T dan meningkatkan aktivitas sel NK di dalam limpa. IL-18 umumnya merupakan sekresi makrofaga dan sel Kupffer.^[4]

Peningkatan ekspresi IL-18 ditemukan pada beberapa jenis kanker, adenomiosis,^[5] dan Hashimoto tiroiditis.^[6]

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Rujukan

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ (Inggris) "IL18 interleukin 18 (interferon-gamma-inducing factor) [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-11-28.
^ (Inggris) "Cloning of a new cytokine that induces IFN-gamma production by T cells". Department of Bacteriology, Hyogo College of Medicine; Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K, et al. Diakses tanggal 2010-11-28.
^ (Inggris) "Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients". Department of Obstetrics and Gynecology, Lin-Kou Medical Center, Chang Gung Memorial Hospital; Huang HY, Yu HT, Chan SH, Lee CL, Wang HS, Soong YK. Diakses tanggal 2010-11-28.
^ (Inggris) "Thyrocyte interleukin-18 expression is up-regulated by interferon-γ and may contribute to thyroid destruction in Hashimoto's thyroiditis". Department of Endocrinology and Metabolism, Peking University Third Hospital; Liu Z, Wang H, Xiao W, Wang C, Liu G, Hong T. Diakses tanggal 2010-11-28.

Artikel bertopik biokimia ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] (Inggris) "IL18 interleukin 18 (interferon-gamma-inducing factor) [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-11-28.

[4] (Inggris) "Cloning of a new cytokine that induces IFN-gamma production by T cells". Department of Bacteriology, Hyogo College of Medicine; Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K, et al. Diakses tanggal 2010-11-28.

[5] (Inggris) "Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients". Department of Obstetrics and Gynecology, Lin-Kou Medical Center, Chang Gung Memorial Hospital; Huang HY, Yu HT, Chan SH, Lee CL, Wang HS, Soong YK. Diakses tanggal 2010-11-28.

[6] (Inggris) "Thyrocyte interleukin-18 expression is up-regulated by interferon-γ and may contribute to thyroid destruction in Hashimoto's thyroiditis". Department of Endocrinology and Metabolism, Peking University Third Hospital; Liu Z, Wang H, Xiao W, Wang C, Liu G, Hong T. Diakses tanggal 2010-11-28.

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Interleukin-18

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