Interleukin-6

IL6
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	4O9H, 1ALU, 1IL6, 1P9M, 2IL6, 4CNI, 4J4L, 4NI7, 4NI9, 4ZS7
Pengidentifikasi
Alias	IL6, BSF2, HGF, HSF, IFNB2, IL-6, BSF-2, CDF, IFN-beta-2, interleukin 6
ID eksternal	OMIM: 147620 MGI: 96559 HomoloGene: 502 GeneCards: IL6
Lokasi gen (Tikus)
Kr.	Kromosom 5 (tikus)
Akhir	30,224,979 bp
Pola ekspresi RNA
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• cytokine activity; • growth factor activity; • interleukin-6 receptor binding; • GO:0001948, GO:0016582 Ikatan protein plasma;
Komponen seluler	• extracellular region; • interleukin-6 receptor complex; • extracellular space; • endoplasmic reticulum lumen;
Proses biologis	• regulation of angiogenesis; • positive regulation of translation; • platelet activation; • humoral immune response; • defense response to virus; • response to peptidoglycan; • neuron projection development; • GO:0051637 defense response to Gram-positive bacterium; • negative regulation of fat cell differentiation; • positive regulation of peptidyl-serine phosphorylation; • positive regulation of leukocyte chemotaxis; • positive regulation of T cell proliferation; • positive regulation of interleukin-6 production; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of acute inflammatory response; • inflammatory response; • negative regulation of collagen biosynthetic process; • positive regulation of MAPK cascade; • hepatic immune response; • monocyte chemotaxis; • positive regulation of DNA-binding transcription factor activity; • negative regulation of apoptotic process; • positive regulation of osteoblast differentiation; • positive regulation of NF-kappaB transcription factor activity; • acute-phase response; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 respons imun; • regulation of vascular endothelial growth factor production; • positive regulation of chemokine production; • negative regulation of lipid storage; • neutrophil mediated immunity; • positive regulation of smooth muscle cell proliferation; • positive regulation of type B pancreatic cell apoptotic process; • response to glucocorticoid; • GO:0051636 defense response to Gram-negative bacterium; • positive regulation of cell population proliferation; • positive regulation of apoptotic process; • positive regulation of B cell activation; • modifikasi pascatranslasi; • regulation of signaling receptor activity; • positive regulation of tyrosine phosphorylation of STAT protein; • neutrophil apoptotic process; • negative regulation of cell population proliferation; • GO:1901313 positive regulation of gene expression; • endocrine pancreas development; • negative regulation of bone resorption; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • glucagon secretion; • cellular response to hydrogen peroxide; • cellular response to lipopolysaccharide; • T-helper 17 cell lineage commitment; • positive regulation of T-helper 2 cell cytokine production; • negative regulation of interleukin-1-mediated signaling pathway; • cytokine-mediated signaling pathway; • interleukin-6-mediated signaling pathway; • positive regulation of receptor signaling pathway via JAK-STAT; • GO:0072468 signal transduction;
	Sumber:Amigo / QuickGO
Ortolog
	3569
	16193
	ENSG00000136244
	ENSMUSG00000025746
	P05231
	P08505
	NM_000600; NM_001318095; NM_001371096
	NM_031168; NM_001314054
	NP_000591; NP_001305024; NP_001358025
	NP_001300983; NP_112445
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Interleukin-6 (bahasa Inggris: Interleukin 6, Interferon beta-2, IFNB2, B cell differentiation factor, B cell stimulatory factor 2, BSF2, Hepatocyte stimulatory factor, HSF, Hybridoma growth factor, HGF, IL-6) adalah sitokina yang disekresi dari jaringan tubuh ke dalam plasma darah, terutama pada fase infeksi akut atau kronis, dan menginduksi respon peradangan transkriptis melalui pencerap IL-6 RA, menginduksi maturasi sel B.^[4] dan pencerap gp130.^[5]

Rujukan

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025746 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ (Inggris) "IL6 interleukin 6 (interferon, beta 2) [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-07-29.
^ (Inggris) "INTERLEUKIN 6; IL6". OMIM. Diakses tanggal 2010-07-29.

Artikel bertopik biokimia ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000025746 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] (Inggris) "IL6 interleukin 6 (interferon, beta 2) [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-07-29.

[5] (Inggris) "INTERLEUKIN 6; IL6". OMIM. Diakses tanggal 2010-07-29.

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