Grand Prix Sepeda Motor musim 1949 menjadi musim pertama F.I.M. menyelenggarakan balap motor. Pada musim ini terdapat 5 kelas; 500cc, 350cc, 250cc, 125cc and Sidecars 600cc. Itu dimulai pada 17 Juni, dengan Isle of Man TT dan diakhiri dengan Grand Prix Nations pada 4 September.

Ronde	Tanggal	Grand Prix	Sirkuit	Pemenang 125cc	Pemenang 250cc	Pemenang 350cc	Pemenang 500cc	Pemenang Sidecars 600cc	Laporan
1	17 Juni	Isle of Man TT	Snaefell Mountain Course		Manliff Barrington	Freddie Frith	Harold Daniell		Laporan
2	3 Juli	Grand Prix Swiss	Circuit Bremgarten	Nello Pagani	Bruno Ruffo	Freddie Frith	Leslie Graham	Oliver / Jenkinson	Laporan
3	9 Juli	Dutch TT	TT Circuit Assen	Nello Pagani		Freddie Frith	Nello Pagani		Laporan
4	17 Juli	Grand Prix Belgia	Circuit de Spa-Francorchamps			Freddie Frith	Bill Doran	Oliver / Jenkinson	Laporan
5	20 Agustus	Grand Prix Ulster	Clady Circuit		Maurice Cann	Freddie Frith	Leslie Graham		Laporan
6	4 September	Grand Prix Nations	Autodromo Nazionale Monza	Gianni Leoni	Dario Ambrosini		Nello Pagani	Frigerio / Dobelli	Laporan

Pos Pembalap Motor MAN SUI HOL BEL ULS NAT Poin 1 Leslie Graham AJS 10 1 2 Ret 1 Ret 30 (31) 2 Nello Pagani Gilera 4 1 5 3 1 29 (40) 3 Arciso Artesiani Gilera 2 3 2 Ret 2 25 (32) 4 Bill Doran AJS 8 Ret 1 4 3 23 5 Artie Bell Norton 4 Ret 4 4 2 20 (26) 6 Harold Daniell Norton 1 3 6 7 17 7 Johnny Lockett Norton 2 Ret 5 Ret Ret 13 8 Enrico Lorenzetti Moto Guzzi 10 3 7 9 Ernie Lyons Velocette 3 7 10 Guido Leoni Moto Guzzi 6 Ret 6 4 6 11 Syd Jensen Triumph 5 Ret 9 5 12 Freddie Frith Velocette Ret 5 Ret Ret 5 13 Bruno Bertacchini Moto Guzzi Ret Ret 5 5 14 Jock West AJS 5 5 15 Ken Armstrong AJS 6 0 = Cromie McCandless Norton 6 0 = Cyril Stevens Triumph 6 0 18 Ken Bills Velocette 7 Ret 10 0 19 Harry Turner Norton 18 7 0 20 Umberto Masetti Gilera 7 Ret 0 21 Reg Armstrong AJS 7 0 = Felice Benasedo Moto Guzzi 7 0 23 Harry Hinton Norton 9 8 16 0 24 George Morrison Norton 31 Ret 8 Ret 0 25 Roger Richoz Norton 8 0 = Ricardo Sabbadini Moto Guzzi 8 0 = James Scott Triumph 8 0 28 Oscar Clemencich Gilera 9 Ret 15 0 29 Sante Geminiani Moto Guzzi 9 0 = Hans Kaufmann Gilera 9 0 31 Dante Bianchi Moto Guzzi 10 0 = Georges Cordey Norton 10 0 = Ernie Callahan Triumph 10 0 34 Arthur Wheeler Triumph Ret Ret 11 0 35 Phil Heath Norton 11 Ret 0 36 Adelmo Mandolini Moto Guzzi 11 0 = Benoit Musy Moto Guzzi 11 0 = Drikus Veer Triumph 11 0 38 Oliver Scott Norton Ret 12 15 0 39 Bill Beevers Norton 16 12 Ret Ret Ret 0 40 Antonio Dalle Fusine Gilera 12 Ret 0 = Bill Petch Triumph 12 Ret 0 42 Lodovico Facchinelli Gilera 12 0 43 Edward Nicholls Triumph 13 9 0 44 Guy Newman Norton 13 0 = Nandor Puhony Gilera 13 0 = Orlando Valdinoci Gilera 13 0 = Albert Vertriest Triumph 13 0 48 Alfeo Maramotti Moto Guzzi 14 0 = Eric McPherson AJS 14 0 = Jacques Schot Norton 14 0 = László Szabó Gilera 14 0 = Jules Tacheny Triumph 14 0 53 Roy Evans Norton 15 0 = Gerard Hoek BMW 15 0 55 Jack Bailey Triumph 17 Ret 0 56 Johnny Hodgkin Norton 19 0 57 Dick Addie Norton 20 0 58 Albert Moule Triumph 21 0 59 George Paterson Triumph 22 0 60 Bob Matthews Norton 23 0 61 George Hayden Norton 24 0 62 John Purnell Norton 25 0 63 Lesly Hill Norton 26 0 64 Arthur Fenn Norton 27 0 65 Harry Francis Norton 28 0 66 Eric Hardy Norton 29 0 67 Jack Brett Norton 30 0 68 Lennart Fenning Norton 32 0 69 Rob Weston Norton 33 0 70 Joe Glazebrook Triumph 34 0 71 Joe Dent Norton 35 0 - Bob Foster Moto Guzzi Ret Ret Ret Ret 0 - Carlo Bandirola Gilera Ret Ret Ret 0 - Eric Briggs Norton Ret Ret Ret 0 - Les Dear Norton Ret Ret Ret 0 - Ted Frend AJS Ret Ret Ret 0 - Fergus Anderson Moto Guzzi Ret Ret 0 - Wilf Billington Norton Ret Ret 0 - Norman Croft Triumph Ret Ret 0 - Frank Fry Norton Ret Ret 0 - Eric Oliver Norton Ret Ret 0 - Ernie Thomas Triumph Ret Ret 0 - David Whitworth Triumph Ret Ret 0 - Dario Ambrosini Gilera Ret 0 - Syl Anderton Triumph Ret 0 - Syd Barnett Norton Ret 0 - Jean Behra Moto Guzzi Ret 0 - Aldo Bernardoni Gilera Ret 0 - Ernie Braine Norton Ret 0 - Charlie Brett Velocette Ret 0 - Aldo Brini Gilera Ret 0 - Gerard Carter Norton Ret 0 - Javier de Ortueta Norton Ret 0 - Roland Dumond Moto Guzzi Ret 0 - Juhan Franta Moto Guzzi Ret 0 - Auguste Goffin Triumph Ret 0 - Arthur Good Norton Ret 0 - Hans Haldemann Moto Guzzi Ret 0 - Piet Knijnenburg BMW Ret 0 - Roger Laurent Moto Guzzi Ret 0 - Sid Lawton Triumph Ret 0 - Reg Lee Norton Ret 0 - Leon Martin Gilera Ret 0 - Reginald MacDonald Triumph Ret 0 - Tommy McEwans Triumph Ret 0 - Armando Miele Gilera Ret 0 - Stan Miller Norton Ret 0 - Bert Myers Triumph Ret 0 - Billy Graham Norton Ret 0 - Ashley Len Parry Norton Ret 0 - Hub Pellikaan BMW Ret 0 - Henry Pinnington Norton Ret 0 - Charlie Salt Norton Ret 0 - Emilio Soprani Gilera Ret 0 - Jan Veer Triumph Ret 0 - Roy Walker Norton Ret 0 - Tom Wycherley Norton Ret 0 Pos Pembalap Motor MAN SUI HOL BEL ULS NAT Poin

Warna Hasil Emas Pemenang Perak Posisi ke-2 Perunggu Posisi ke-3 Hijau Finis, dengan poin Biru Finis, tanpa poin Tidak terklasifikasi (NC) Ungu Tidak finis (Ret) Merah Tidak terkualifikasi (DNQ) Tidak mengikuti pra-kualifikasi (DNPQ) Hitam Diskualifikasi (DSQ) Putih Tidak start (DNS) Mengundurkan diri (WD) Balapan dibatalkan (C) Kosong Tidak berpartisipasi Dikecualikan (EX) Tebal – Pole Miring – Lap Tercepat

Pos	Konstruktor							Poin
1	AJS	6	1	2	1	1	3	32 (48)
2	Gilera	–	2	1	2	3	1	31 (46)
3	Norton	1	3	4	4	2	Ret	25 (37)
4	Moto Guzzi	Ret	6	10	3	Ret	4	13
5	Velocette	3	5	Ret	10	–	–	12
6	Triumph	5	Ret	11	9	8	Ret	5
–	BMW	–	–	15	–	–	–	0

Pos	Pembalap	Negara	Mesin	Poin	Menang
1	Freddie Frith	Britania Raya	Velocette	33	5
2	Reg Armstrong	Irlandia	AJS	18	0
3	Bob Foster	Britania Raya	Velocette	16	0
4	Eric McPherson	Australia	AJS	16	0
5	Johnny Lockett	Britania Raya	Norton	14	0
6	David Whitworth	Britania Raya	Velocette	12	0
7	Leslie Graham	Britania Raya	AJS	8	0
8	Ernie Lyons	Irlandia	Velocette	8	0
9	Charlie Salt	Britania Raya	Velocette	8	0
10	Bill Doran	Britania Raya	AJS	7	0

Pos	Rider	Negara	Mesin	Poin	Menang
1	Bruno Ruffo	Italia	Moto Guzzi	24	1
2	Dario Ambrosini	Italia	Benelli	19	1
3	Ronald Mead	Britania Raya	Norton	13	0
4	Maurice Cann	Britania Raya	Moto Guzzi	11	1
5	Claudio Mastellari	Italia	Moto Guzzi	11	0
6	Manliff Barrington	Irlandia	Moto Guzzi	10	1
7	Russel Wood	Afrika Selatan	Moto Guzzi	9	0
8	Fergus Anderson	Britania Raya	Moto Guzzi	8	0
9	Gianni Leoni	Italia	Moto Guzzi	8	0
10	Umberto Masetti	Italia	Benelli	7	0

Pos	Pembalap	Negara	Mesin	Poin	Menang
1	Nello Pagani	Italia	Mondial	27	2
2	Renato Magi	Italia	Morini	14	0
3	Umberto Masetti	Italia	Morini	13	0
4	Carlo Ubbiali	Italia	Mondial	13	0
5	Gianni Leoni	Italia	Mondial	11	1
6	Oscar Clemengich	Italia	Mondial	8	0
7	Umberto Praga	Italia	Mondial	7	0
8	Celeste Cavaciuti	Italia	Mondial	7	0
9	Franco Bertoni	Italia	MV Agusta	6	0
10	Giuseppe Matucci	Italia	MV Agusta	5	0

Pos	Pembalap	Negara	Mesin	Poin	Menang
1	Eric Oliver / Denis Jenkinson	Britania Raya	Norton	27	2
2	Ercole Frigerio / Lorenzo Dobelli	Italia	Gilera	18	1
3	Frans Vanderschrick / Martin Whitney	Belgia/Britania Raya	Norton	16	0
4	Ernesto Merlo / Aldo Veglio	Italia	Gilera	13	0
5	Albino Milani / Ezio Ricotti	Italia	Gilera	12	1
6	Hans Haldemann / Herbert Läderach	Swiss	Norton	8	0
7	Roland Benz / Max Hirzel	Swiss	BMW	6	0
8	Jakob Keller / Ernst Brutschi	Swiss	Gilera	6	0
9	Peter 'Pip' Harris / Neil Smith	Britania Raya	Norton	5	0

• Büla, Maurice & Schertenleib, Jean-Claude (2001). Sirkus Kontinental 1949–2000. Chronosports S.A. ISBN 2-940125-32-5
• "Klasemen 500cc". MotoGP. Diarsipkan dari asli tanggal 2012-09-18. Diakses tanggal 6 Juli 2010.
• "Klasemen 250cc". MotoGP. Diarsipkan dari asli tanggal 2021-11-22. Diakses tanggal 6 Juli 2010.
• "Klasemen 125cc". MotoGP. Diarsipkan dari asli tanggal 2021-11-22. Diakses tanggal 6 Juli 2010.

• "Situs Resmi MotoGP". Diarsipkan dari asli tanggal 2023-08-06. Diakses tanggal 2013-07-22.