Grand Prix Sepeda Motor musim 1959 adalah musim ke-11 Grand Prix Sepeda Motor F.I.M.. Musim terdiri dari tujuh balapan Grand Prix di lima kelas: 500cc, 350cc, 250cc, 125cc dan Sidecars 500cc. Itu dimulai pada 17 Mei, dengan Grand Prix Prancis dan diakhiri dengan Grand Prix Nations di Italia pada tanggal 6 September.

Ronde	Tanggal	Grand Prix	Sirkuit	Pemenang 125cc	Pemenang 250cc	Pemenang 350cc	Pemenang 500cc	Pemenang Sidecars 500cc	Laporan
1	17 Mei	Grand Prix Prancis	Charade Circuit			John Surtees	John Surtees	Scheidegger / Burkhardt	Laporan
2	6 Juni	Isle of Man TT	Snaefell Mountain	Tarquinio Provini	Tarquinio Provini	John Surtees	John Surtees	Schneider / Strauß	Laporan
3	14 Juni	Grand Prix Jerman	Hockenheimring	Carlo Ubbiali	Carlo Ubbiali	John Surtees	John Surtees	Camathias / Cecco	Laporan
4	27 Juni	Dutch TT	TT Circuit Assen	Carlo Ubbiali	Tarquinio Provini	Bob Brown †	John Surtees	Camathias / Cecco	Laporan
5	5 Juli	Grand Prix Belgia	Spa-Francorchamps	Carlo Ubbiali	Gary Hocking †		John Surtees	Schneider / Strauß	Laporan
6	26 Juli	Grand Prix Swedia	Råbelövsbanan	Tarquinio Provini	Gary Hocking	John Surtees	Bob Brown †		Laporan
7	8 Agustus	Grand Prix Ulster	Dundrod Circuit	Mike Hailwood	Gary Hocking	John Surtees	John Surtees		Laporan
8	6 September	Grand Prix Nations††	Monza	Ernst Degner	Carlo Ubbiali	John Surtees	John Surtees		Laporan

† Perlombaan tidak diperhitungkan untuk Kejuaraan Dunia.

†† Grand Prix Nations juga menggelar balapan non-kejuaraan 175 cc, yang dimenangkan oleh pembalap Italia, Francesco Villa.

Poin diberikan kepada enam finis teratas di setiap balapan. Hanya empat balapan terbaik yang dihitung di kelima kelas: kejuaraan Sidecars, 125cc, 250cc, 350cc, dan 500cc.

Pos Pembalap Motor FRA MAN GER HOL BEL ULS NAC Poin 1 John Surtees MV Agusta 1 1 1 1 1 1 1 32 (56) 2 Remo Venturi MV Agusta 2 2 3 5 2 22 (24) 3 Bob Brown Norton 9 3 3 2 4 5 4 17 (22) 4 Geoff Duke Norton 9 3 3 3 12 5 Gary Hocking Norton 3 Ret Ret 2 Ret Ret 10 6 Bob McIntyre Norton 5 2 8 7 Alistair King Norton 2 6 7 8 Dickie Dale BMW 4 Ret Ret 4 8 7 Ret 6 9 Terry Shepherd Norton 5 Ret 4 5 10 John Hempleman Norton 17 5 Ret Ret 8 5 4 11 Derek Powell Matchless 4 14 3 12 Ken Kavanagh Norton DNS 4 Ret Ret 3 13 Paddy Driver Norton 6 6 Ret Ret Ret 6 3 14 Jim Redman Norton Ret Ret 5 9 Ret Ret 2 15 Bob Anderson Norton 8 Ret Ret 6 1 16 Ron Miles Norton 12 12 6 11 1 17 Alois Huber BMW 6 1 18 Tom Phillis Norton 7 16 Ret Ret 7 Ret 0 19 Hans-Günter Jäger BMW 11 10 7 16 8 0 20 Ernst Hiller BMW 8 Ret 7 0 21 Geoff Tanner Norton Ret 7 9 11 0 22 Alan Shepherd Matchless 7 9 0 23 George Catlin Matchless 8 0 = Anton Elbersen BMW 8 0 25 Ralph Rensen Norton 10 9 10 0 26 Karl Untersteggaber Norton 9 0 27 Derek Minter Norton Ret Ret 10 0 = Peter Pawson Norton 10 Ret Ret 0 29 Paolo Campanelli Norton 10 0 30 Jacques Insermini Norton Ret 11 0 = Brian Setchell Norton 11 0 = Evert Carlsson BMW 11 0 33 Raymond Bogaerdt Norton Ret 12 0 34 Jacques Collot Norton 12 0 = Vasco Loro Norton 12 0 = Stephen Murray Matchless 12 0 37 Mike Hailwood MV Agusta / Norton Ret 13 Ret 0 = Alfredo Milani Gilera Ret Ret 13 0 39 Guy Ligier Norton 13 0 = Rudolf Gläser Norton 13 0 = Robin Fitton Norton Ret 13 0 = Bill Smith Matchless 13 0 43 Yvon Callede Norton 14 0 = Ewan Haldane Norton 14 0 = Charly Maubert Norton 14 0 = Jules Nies Matchless 14 0 47 Don Chapman Norton Ret 15 0 48 Maurice de Polo Norton 15 0 = Raymond Hanset Norton 15 0 = Bob Rowbottom Norton 15 0 51 Tommy McLeod Norton 16 0 = Albert Montagne Norton 16 0 53 Jean-Pierre Bayle Norton Ret Ret 17 0 = Stan Cameron Matchless Ret 17 0 55 Joe Wright Norton 17 0 56 Harry Grant Norton / Matchless 18 22 0 = Jimmy Jones Norton 18 0 58 William McCosh Matchless 19 0 = Fred Stevens AJS 19 0 60 Martin Brosnan Norton 20 0 = Ed LaBelle BMW 20 0 62 George Northwood Norton 21 0 = Willie White Norton 21 0 64 Vernon Cottle Norton 22 0 66 Frank Gordon Norton 23 0 67 Ernie Oliver AJS 24 0 68 Jack Shannon BSA 25 0 69 John Brown Norton 26 0 - Eric Hinton Norton Ret Ret Ret 0 - Jimmy Buchan Jr Norton Ret Ret 0 - Jack Findlay Norton Ret Ret 0 - John Hartle MV Agusta Ret Ret 0 - Llewelyn Ranson Norton Ret Ret 0 - Ernesto Brambilla MV Agusta Ret 0 - Jack Brett Norton Ret 0 - Jack Bullock Matchless Ret 0 - Louis Carr Norton Ret 0 - Eric Cheers Norton Ret 0 - Artemio Cirelli Gilera Ret 0 - Barry Cortvriend Matchless Ret 0 - George Costain Norton Ret 0 - Adolfo Covi Norton Ret 0 - Dick Creith Norton Ret 0 - Davy Crawford Norton Ret 0 - Bruce Daniels Norton Ret 0 - Bertie Farlow Norton Ret 0 - Ray Fay Norton Ret 0 - Peter Ferbrache Matchless Ret 0 - Bob Ferguson Norton Ret 0 - Ralph Fox AJS Ret 0 - Joe Glazebrook Norton Ret 0 - Roger Graham Norton Ret 0 - Owen Greenwood Triumph Ret 0 - Francesco Guglielminetti Norton Ret 0 - Tom Hesketh Norton Ret 0 - Tommy Holmes BSA Ret 0 - Roy Ingram Norton Ret 0 - Len Ireland Norton Ret 0 - Den Jarman Norton Ret 0 - Lothar John BMW Ret 0 - Host Kassner Norton Ret 0 - Luigi Marcelli Norton Ret 0 - Angus Martin Norton Ret 0 - Giuseppe Mantelli Gilera Ret 0 - Emanuele Maugliani Gilera Ret 0 - Robert McCracken Norton Ret 0 - Fritz Messerli Ret 0 - Syd Mizen Norton Dunstall Ret 0 - Albert Moule Norton Ret 0 - Frank Perris Norton Ret 0 - Harry Plews AJS Ret 0 - Ladislaus Richter Norton Ret 0 - Bill Robertson Norton Ret 0 - Walter Scheimann Norton Ret 0 - Toni Schmitz Norton Ret 0 - Ray Spence Norton Ret 0 - Don Tickle Norton Ret 0 - Alan Trow Norton Ret 0 - Dino Valbonesi Gilera Ret 0 - Michel Valentin Ret 0 - Martinus van Son Norton Ret 0 - Roberto Vigorito Norton Ret 0 - Arthur Wheeler AJS Ret 0 - Lewis Young Norton Ret 0 - Benedetto Zambotti Gilera Ret 0 Pos Pembalap Motor FRA MAN GER HOL BEL ULS NAC Poin

Kunci Warna Hasil Emas Pemenang Perak Posisi kedua Perunggu Posisi ketiga Hijau Finis zona poin Biru Finis tanpa poin Finis tak terklasifikasi (NC) Ungu Turun balapan (Retired/DNF) Merah Tidak terkualifikasi (DNQ) Tidak lolos prakualifikasi (DNPQ) Hitam Didiskualifikasi (DSQ) Putih Tidak memulai balapan (DNS) Mengundurkan diri (WD) Lomba dibatalkan (C) Kosong Tidak latihan (DNP) Tidak datang (DNA) Dikecualikan (EX) Anotasi Arti Tebal Pole position Miring Lap tercepat

Pos	Pembalap	Negara	Mesin	Poin	Menang
1	John Surtees	Britania Raya	MV Agusta	48	6
2	John Hartle	Britania Raya	MV Agusta	16	0
3	Bob Brown	Australia	Norton	14	0
4	Gary Hocking	Rhodesia	Norton	12	0
5	Geoff Duke	Britania Raya	Norton	10	0
6	Remo Venturi	Italia	MV Agusta	6	0
7	Dickie Dale	Britania Raya	AJS	6	0
8	John Hempleman	Selandia Baru	Norton	6	0
9	Bob Anderson	Britania Raya	Norton	5	0
10	Alistair King	Britania Raya	Norton	4	0
=	Ernesto Brambilla	Italia	MV Agusta	4	0
12	Paddy Driver	Afrika Selatan	Norton	4	0
13	Mike Hailwood	Britania Raya	AJS	2	0
=	Tom Phillis	Australia	Norton	2	0
15	Jim Redman	Rhodesia	Norton	2	0
16	Terry Shepherd	Britania Raya	Norton	1	0
=	Dave Chadwick	Britania Raya	Norton	1	0
=	Gilberto Milani	Italia	Norton	1	0

Pos	Pembalap	Negara	Mesin	Poin	Menang
1	Carlo Ubbiali	Italia	MV Agusta	28	2
2	Tarquinio Provini	Italia	MV Agusta	16	2
=	Gary Hocking	Rhodesia	MZ	16	2
4	Ernst Degner	Jerman Timur	MZ	14	0
5	Mike Hailwood	Britania Raya	Mondial	13	0
6	Emilio Mendogni	Italia	Morini	10	0
7	Derek Minter	Britania Raya	Morini	7	0
8	Tommy Robb	Britania Raya	GMS-MZ	7	0
9	Horst Fügner	Jerman Timur	MZ	6	0
10	Geoff Duke	Britania Raya	Benelli	5	0
11	Dave Chadwick	Britania Raya	MV Agusta	4	0
12	Libero Liberati	Italia	Morini	3	0
13	Horst Kassner	Jerman Barat	NSU	2	0
=	Phil Carter	Britania Raya	NSU	2	0
=	Luigi Taveri	Swiss	MZ	2	0
16	Rudi Thalhammer	Austria	NSU	1	0
=	Dickie Dale	Britania Raya	Benelli	1	0
18	Günter Beer	Jerman Barat	Adler	1	0

Pos	Pembalap	Negara	Mesin	Poin	Menang
1	Carlo Ubbiali	Italia	MV Agusta	30	3
2	Tarquinio Provini	Italia	MV Agusta	28	2
3	Mike Hailwood	Britania Raya	Ducati	20	1
4	Luigi Taveri	Swiss	MZ / Ducati	14	0
5	Ernst Degner	Jerman Timur	MZ	13	1
6	Bruno Spaggiari	Italia	Ducati	8	0
7	Derek Minter	Britania Raya	MZ	8	0
8	Ken Kavanagh	Australia	Ducati	8	0
9	Gary Hocking	Rhodesia	MZ / MV Agusta	7	0
10	Horst Fügner	Jerman Timur	MZ	6	0
11	Werner Musiol	Jerman Timur	MZ	4	0
12	Francesco Villa	Italia	Ducati	3	0
13	Alberto Pagani	Italia	Ducati	2	0
14	Naomi Taniguchi	Jepang	Honda	1	0
=	Karl Kronmüller	Jerman Barat	Ducati	1	0
=	Ulf Svensson	Swedia	Ducati	1	0
=	Arthur Wheeler	Britania Raya	Ducati	1	0

• Büla, Maurice & Schertenleib, Jean-Claude (2001). Continental Circus 1949-2000. Chronosports S.A. ISBN 2-940125-32-5
• "Situs Resmi MotoGP". Diarsipkan dari asli tanggal 2 Maret 2012. Diakses tanggal 6 Juli 2010.