Penghalang saluran kalsium dihidropiridina
Penghambat saluran kalsium dihidropiridina (lebih dikenal sebagai "-dipin") adalah turunan dari 1,4-dihidropiridina yang digunakan sebagai penghalang saluran kalsium tipe-L.[1] Golongan obat ini digunakan dalam pengobatan hipertensi.[2]
Dibandingkan dengan penghalang saluran kalsium tipe-L tertentu lainnya (misalnya golongan fenilalkilamina seperti verapamil) yang memiliki aksi signifikan pada jantung, penghalang saluran kalsium dihidropiridina menurunkan tekanan darah terutama dengan merelaksasi otot polos dinding pembuluh darah.[3]
Anggota
Penghambat saluran kalsium kelas L dihidropiridin meliputi (dalam urutan abjad, nama merek bervariasi di berbagai negara):
| Nama | Gambar | Merek | Sitasi |
|---|---|---|---|
| Amlodipin |  |
A-B Vask, Cardisan, Intervask, Zevask, Norvasc, lainnya | [4] |
| Aranidipin |  |
Sapresta (サプレスタ) | [5] |
| Azelnidipin |  |
CalBlock (カルブロック) | [6] |
| Barnidipin |  |
Vasexten, Libradin, Cyress, HypoCa | [7] |
| Benidipin |  |
Coniel | [8] |
| Cilnidipine |  |
Atelec (アテレック), Cilacar, Cinalong, Siscard | [9] |
| Klevidipin |  |
Cleviprex | [10] |
| Cronidipine |  |
[11] | |
| Darodipin |  |
[12] | |
| Deksniguldipin |  |
[13] | |
| Efonidipin |  |
Landel (ランデル) | [14] |
| Elgodipin |  |
[15] | |
| Elnadipin |  |
[16] | |
| Felodipin |  |
Plendil | [17] |
| Flordipin |  |
[18] | |
| Furnidipin |  |
[19] | |
| Iganidipin |  |
[20] | |
| Isradipin |  |
DynaCirc | [21] |
| Lasidipin |  |
Lacipil, Motens, Sakure | |
| Lemildipin |  |
||
| Lerkanidipin |  |
Zanidip, Leridip | |
| Levamlodipin |  |
EsCordi Cor | |
| Levniguldipin |  |
||
| Manidipin |  |
Manyper, Caslot, Madipine | |
| Nikardipin |  |
Cardene, Dipitenz, Nicarfion, Nidaven, Tensilo, Verdif | |
| Nifedipin |  |
Adalat, Farmalat, Nifedin, Procardia, lainnya | |
| Niguldipin |  |
||
| Niludipin |  |
||
| Nilvadipin |  |
Nivadil | |
| Nimodipin |  |
Nimotop, Nimox, Nymalize, dll | |
| Nisoldipin |  |
Sular, Baymycard, Syscor | |
| Nitrendipin |  |
Baypress, Cardif, Nitrepin, Baylotensin | |
| Olradipin |  |
||
| Oksodipin |  |
||
| Palonidipin |  |
||
| Pranidipin |  |
Acalas | |
| Riodipin |  |
||
| Sagandipin |  |
||
| Sornidipin |  |
||
| Teludipin |  |
||
| Tiamdipin |  |
||
| Trombodipin |  |
||
| Vatanidipin |  |
Obat farmasi finerenona juga merupakan turunan dihidropiridina, tetapi tidak bertindak sebagai penghalang saluran kalsium, melainkan sebagai antimineralokortikoid.[22]
Referensi
- ^ Bladen, Chris; Gündüz, Miyase Gözde; Şimşek, Rahime; Şafak, Cihat; Zamponi, Gerald W. (2014-10-23). "Synthesis and evaluation of 1,4-dihydropyridine derivatives with calcium channel blocking activity". Pflügers Archiv: European Journal of Physiology. 466 (7): 1355–1363. doi:10.1007/s00424-013-1376-z. ISSN 1432-2013. PMID 24149495. S2CID 253888496.
- ^ Xu, Lei; Li, Dan; Tao, Li; Yang, Yanling; Li, Youyong; Hou, Tingjun (2016). "Binding mechanisms of 1,4-dihydropyridine derivatives to L-type calcium channel Cav1.2: a molecular modeling study". Molecular BioSystems. 12 (2): 379–390. doi:10.1039/c5mb00781j. ISSN 1742-2051. PMID 26673131.
- ^ Frishman, William H. (2007). "Calcium channel blockers: differences between subclasses". American Journal of Cardiovascular Drugs. 7 (Suppl 1): 17–23. doi:10.2165/00129784-200707001-00003. ISSN 1175-3277. PMID 19845073. S2CID 21199295.
- ^ Bulsara, Kishen G.; Cassagnol, Manouchkathe (2022), "Amlodipine", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 30137793, diakses tanggal 2023-01-05
- ^ Okumura, K.; Ichihara, K.; Nagasaka, M. (1997). "Effects of aranidipine, a novel calcium channel blocker, on mechanical responses of the isolated rat portal vein: comparison with typical calcium channel blockers and potassium channel openers". Journal of Cardiovascular Pharmacology. 29 (2): 209–215. doi:10.1097/00005344-199702000-00009. ISSN 0160-2446. PMID 9057070.
- ^ Wellington, Keri; Scott, Lesley J. (2003). "Azelnidipine". Drugs. 63 (23): 2613–2621, discussion 2623–2624. doi:10.2165/00003495-200363230-00004. ISSN 0012-6667. PMID 14636080. S2CID 263994294.
- ^ Malhotra, H. S.; Plosker, G. L. (2001). "Barnidipine". Drugs. 61 (7): 989–996, discussion 997–998. doi:10.2165/00003495-200161070-00007. ISSN 0012-6667. PMID 11434453. S2CID 263999687.
- ^ Opie, Lionel H. (2013-01-01), Opie, Lionel H.; Gersh, Bernard J. (ed.), "3 - Calcium channel blockers", Drugs for the Heart (Eighth Edition) (dalam bahasa Inggris), Philadelphia: W.B. Saunders, hlm. 64–92, ISBN 978-1-4557-3322-4, diakses tanggal 2023-01-05
- ^ Shete, Mukesh Madhukar (2016). "Cilnidipine: Next Generation Calcium Channel Blocker". The Journal of the Association of Physicians of India. 64 (4): 95–99. ISSN 0004-5772. PMID 27734656.
- ^ Deeks, Emma D.; Keating, Gillian M.; Keam, Susan J. (2009). "Clevidipine: a review of its use in the management of acute hypertension". American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions. 9 (2): 117–134. doi:10.1007/BF03256583. ISSN 1175-3277. PMID 19331440.
- ^ PubChem. "Cronidipine". pubchem.ncbi.nlm.nih.gov (dalam bahasa Inggris). Diakses tanggal 2023-01-05.
- ^ Matucci, R.; Ottaviani, M. F.; Barbieri, M.; Cerbai, E.; Mugelli, A. (2009-02-12). "Protective effect of darodipine, a calcium antagonist, on rat cardiomyocytes against oxygen radical-mediated injury". British Journal of Pharmacology. 122 (7): 1353–1360. doi:10.1038/sj.bjp.0701525. ISSN 0007-1188. PMC 1565083. PMID 9421282.
- ^ Hahn, K. A.; Legendre, A. M.; Schuller, H. M. (1997). "Amputation and dexniguldipine as treatment for canine appendicular osteosarcoma". Journal of Cancer Research and Clinical Oncology. 123 (1): 34–38. doi:10.1007/BF01212612. ISSN 0171-5216. PMC 12200756. PMID 8996538. S2CID 21129242.
- ^ Tanaka, Hikaru; Shigenobu, Koki (2002). "Efonidipine hydrochloride: a dual blocker of L- and T-type ca(2+) channels". Cardiovascular Drug Reviews. 20 (1): 81–92. doi:10.1111/j.1527-3466.2002.tb00084.x. ISSN 0897-5957. PMID 12070536.
- ^ Tamargo, J.; López-Sendón, J.; Delpón, E.; González-Morales, M.; de Miguel, E. (1991). "Cardiovascular effects of the new dihydropyridine derivative elgodipine". Arzneimittel-Forschung. 41 (9): 895–900. ISSN 0004-4172. PMID 1796916.
- ^ PubChem. "Elnadipine". pubchem.ncbi.nlm.nih.gov (dalam bahasa Inggris). Diakses tanggal 2023-01-05.
- ^ Bansal, Agam B.; Khandelwal, Gaurav (2022), "Felodipine", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 31194320, diakses tanggal 2023-01-05
- ^ Mayhan, W. G.; Heistad, D. D. (1985). "Effect of flordipine on cerebral blood flow". The Journal of Pharmacology and Experimental Therapeutics. 235 (1): 92–97. doi:10.1016/S0022-3565(25)23906-4. ISSN 0022-3565. PMID 4045730.
- ^ Krzemiński, Tadeusz F.; Hudziak, Damian; Sielańczyk, Andrzej W.; Porc, Maurycy; Kedzia, Agnieszka (2008). "Differential effects of furnidipine and its active metabolites in rat isolated working heart". Vascular Pharmacology. 49 (2–3): 91–96. doi:10.1016/j.vph.2008.06.005. ISSN 1537-1891. PMID 18656554.
- ^ Ishii, Kiyoshi; Matsuo, Hiroshi; Fukaya, Yasuhiro; Tanaka, Sumiyoshi; Sakaki, Hideyuki; Waki, Mitsunori; Araie, Makoto (2003). "Iganidipine, a new water-soluble Ca2+ antagonist: ocular and periocular penetration after instillation". Investigative Ophthalmology & Visual Science. 44 (3): 1169–1177. doi:10.1167/iovs.02-0482. ISSN 0146-0404. PMID 12601046.
- ^ Schachter, M. (1991). "Isradipine". Journal of Clinical Pharmacy and Therapeutics. 16 (2): 79–91. doi:10.1111/j.1365-2710.1991.tb00288.x. ISSN 0269-4727. PMID 1830320. S2CID 221850085.
- ^ Tushar, Chopra; Okusa, Mark Douglas (2019-01-01), Ronco, Claudio; Bellomo, Rinaldo; Kellum, John A.; Ricci, Zaccaria (ed.), "Chapter 63 - Aldosterone Antagonists, Amiloride, and Triamterene", Critical Care Nephrology (Third Edition) (dalam bahasa Inggris), Philadelphia: Elsevier, hlm. 368–373.e1, ISBN 978-0-323-44942-7, diakses tanggal 2023-01-05
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