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Antagonis reseptor GABA adalah obat yang menghambat kerja GABA. Secara umum, obat-obatan ini menghasilkan efek stimulan dan konvulsan, dan terutama digunakan untuk mengatasi overdosis sedatif.

Contohnya termasuk bikukulina, sekurinina, dan pentetrazol; serta antagonis reseptor GABA_A benzodiazepin flumazenil.

Agen lain yang mungkin memiliki antagonisme reseptor GABA_A termasuk antibiotik siprofloksasin,^[1] asam traneksamat,^[2] tujona,^[3] ginkgo biloba,^[4] dan kudzu.^[5]

Lihat juga

Modulator alosterik negatif reseptor GABA_A

Pranala luar

MeSH GABA+antagonists

Referensi

^ Green, M. A.; Halliwell, R. F. (October 1997). "Selective antagonism of the GABA A receptor by ciprofloxacin and biphenylacetic acid". British Journal of Pharmacology (dalam bahasa Inggris). 122 (3): 584–590. doi:10.1038/sj.bjp.0701411. ISSN 0007-1188. PMC 1564969. PMID 9351519.
^ Roman Furtmüller; Michael G Schlag; Michael Berger; Rudolf Hopf; Sigismund Huck; Werner Sieghart; Heinz Redl (April 2002). "Tranexamic Acid, a Widely Used Antifibrinolytic Agent, Causes Convulsions by a γ-Aminobutyric Acid_A Receptor Antagonistic Effect". Journal of Pharmacology and Experimental Therapeutics. 301 (1): 168–173. doi:10.1124/jpet.301.1.168. PMID 11907171. Diakses tanggal 1 November 2021.
^ Karin M. Höld; Nilantha S. Sirisoma; Tomoko Ikeda; Toshio Narahashi; John E. Casida (April 2000). "α-Thujone (the active component of absinthe): γ-Aminobutyric acid type A receptor modulation and metabolic detoxification". PNAS. 97 (8): 3826–3831. Bibcode:2000PNAS...97.3826H. doi:10.1073/pnas.070042397. PMC 18101. PMID 10725394.
^ Lidija Ivic; Tristan T.J. Sands; Nathan Fishkin; Koji Nakanishi; Arnold R. Kriegstein; Kristian Strømgaard (December 2003). "Terpene Trilactones from Ginkgo biloba Are Antagonists of Cortical Glycine and GABA_A Receptors". Journal of Biological Chemistry. 278 (49): 49279–49285. doi:10.1074/jbc.M304034200. PMID 14504293.
^ Robert M. Swift; Elizabeth R. Aston (March 2015). "Pharmacotherapy for Alcohol Use Disorder: Current and Emerging Therapies". Harvard Review of Psychiatry. 23 (2): 122–133. doi:10.1097/HRP.0000000000000079. PMC 4790835. PMID 25747925.

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[1] Green, M. A.; Halliwell, R. F. (October 1997). "Selective antagonism of the GABA A receptor by ciprofloxacin and biphenylacetic acid". British Journal of Pharmacology (dalam bahasa Inggris). 122 (3): 584–590. doi:10.1038/sj.bjp.0701411. ISSN 0007-1188. PMC 1564969. PMID 9351519.

[2] Roman Furtmüller; Michael G Schlag; Michael Berger; Rudolf Hopf; Sigismund Huck; Werner Sieghart; Heinz Redl (April 2002). "Tranexamic Acid, a Widely Used Antifibrinolytic Agent, Causes Convulsions by a γ-Aminobutyric Acid_A Receptor Antagonistic Effect". Journal of Pharmacology and Experimental Therapeutics. 301 (1): 168–173. doi:10.1124/jpet.301.1.168. PMID 11907171. Diakses tanggal 1 November 2021.

[3] Karin M. Höld; Nilantha S. Sirisoma; Tomoko Ikeda; Toshio Narahashi; John E. Casida (April 2000). "α-Thujone (the active component of absinthe): γ-Aminobutyric acid type A receptor modulation and metabolic detoxification". PNAS. 97 (8): 3826–3831. Bibcode:2000PNAS...97.3826H. doi:10.1073/pnas.070042397. PMC 18101. PMID 10725394.

[4] Lidija Ivic; Tristan T.J. Sands; Nathan Fishkin; Koji Nakanishi; Arnold R. Kriegstein; Kristian Strømgaard (December 2003). "Terpene Trilactones from Ginkgo biloba Are Antagonists of Cortical Glycine and GABA_A Receptors". Journal of Biological Chemistry. 278 (49): 49279–49285. doi:10.1074/jbc.M304034200. PMID 14504293.

[5] Robert M. Swift; Elizabeth R. Aston (March 2015). "Pharmacotherapy for Alcohol Use Disorder: Current and Emerging Therapies". Harvard Review of Psychiatry. 23 (2): 122–133. doi:10.1097/HRP.0000000000000079. PMC 4790835. PMID 25747925.

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Ensiklopedia Dunia

Antagonis reseptor GABA

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Pranala luar

Referensi

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