Ensiklopedia Dunia

Umeklidinium bromida
Data klinis
Nama dagang	Incruse Ellipta
Nama lain	GSK573719A
License data	US DailyMed: bromide Umeclidinium bromide;
Rute; pemberian	Inhalasi (Inhaler serbuk kering)
Kode ATC	R03BB07 (WHO) ; R03AL03 (+vilanterol);
Status hukum
Status hukum	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Hanya resep) ; US: ℞-only ; ℞ (Hanya resep);
Data farmakokinetika
Pengikatan protein	~89%
Metabolisme	Hati (CYP2D6)
Waktu paruh eliminasi	11 jam
Ekskresi	Feses (58%) dan urin (22%)
Pengenal
	Nama IUPAC Difenil-[1-(2-fenilmetoksietil)-1-azoniabisiklo[2.2.2]oktan-4-il]metanol bromida;
Nomor CAS	869113-09-7;
PubChem CID	11519069;
ChemSpider	9693857;
UNII	7AN603V4JV;
KEGG	D10181;
ChEBI	CHEBI:79040;
CompTox Dashboard (EPA)	DTXSID50235966 ;
ECHA InfoCard	100.166.375
Data sifat kimia dan fisik
Rumus	C29H34BrNO2
Massa molar	508,50 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
	SMILES OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3ccccc3)(CC1)CC2.[Br-];
	InChI InChI=1S/C29H34NO2.BrH/c31-29(26-12-6-2-7-13-26,27-14-8-3-9-15-27)28-16-19-30(20-17-28,21-18-28)22-23-32-24-25-10-4-1-5-11-25;/h1-15,31H,16-24H2;1H/q+1;/p-1; Key:PEJHHXHHNGORMP-UHFFFAOYSA-M;

Umeklidinium bromida adalah antagonis muskarinik kerja panjang yang disetujui untuk pengobatan pemeliharaan penyakit paru obstruktif kronik (PPOK).^[3] Obat ini juga disetujui untuk indikasi ini dalam kombinasi dengan vilanterol (sebagai umeklidinium bromida/vilanterol)^[4]^[5] dan juga sebagai kombinasi tiga terapi sebagai flutikason furoat/umeklidinium bromida/vilanterol.^[6] Obat ini tercantum dalam Daftar Obat Esensial Organisasi Kesehatan Dunia.^[7]

Referensi

^ "Prescription medicines: registration of new chemical entities in Australia, 2014". Therapeutic Goods Administration (TGA). 21 June 2022. Diakses tanggal 10 April 2023.
^ "Product monograph brand safety updates". Health Canada. 7 July 2016. Diakses tanggal 3 April 2024.
^ ^a ^b "Incruse Ellipta (umeclidinium inhalation powder) for Oral Inhalation Use. Full Prescribing Information" (PDF). GlaxoSmithKline, Research Triangle Park, NC 27709. Diarsipkan dari asli (PDF) tanggal 10 July 2018. Diakses tanggal 22 February 2016.
^ Feldman GJ, Edin A (December 2013). "The combination of umeclidinium bromide and vilanterol in the management of chronic obstructive pulmonary disease: current evidence and future prospects". Therapeutic Advances in Respiratory Disease. 7 (6): 311–9. doi:10.1177/1753465813499789. PMID 24004659. S2CID 5744282.
^ "FDA Approves Umeclidinium and Vilanterol Combo for COPD". Medscape. December 18, 2013.
^ "TRELEGY ELLIPTA Package Insert" (PDF). GlaxoSmithKline. September 2017. Diakses tanggal 11 July 2020.
^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

[1] "Prescription medicines: registration of new chemical entities in Australia, 2014". Therapeutic Goods Administration (TGA). 21 June 2022. Diakses tanggal 10 April 2023.

[2] "Product monograph brand safety updates". Health Canada. 7 July 2016. Diakses tanggal 3 April 2024.

[PI-3] "Incruse Ellipta (umeclidinium inhalation powder) for Oral Inhalation Use. Full Prescribing Information" (PDF). GlaxoSmithKline, Research Triangle Park, NC 27709. Diarsipkan dari asli (PDF) tanggal 10 July 2018. Diakses tanggal 22 February 2016.

[4] Feldman GJ, Edin A (December 2013). "The combination of umeclidinium bromide and vilanterol in the management of chronic obstructive pulmonary disease: current evidence and future prospects". Therapeutic Advances in Respiratory Disease. 7 (6): 311–9. doi:10.1177/1753465813499789. PMID 24004659. S2CID 5744282.

[5] "FDA Approves Umeclidinium and Vilanterol Combo for COPD". Medscape. December 18, 2013.

[Trelegy_Ellipta_PI-6] "TRELEGY ELLIPTA Package Insert" (PDF). GlaxoSmithKline. September 2017. Diakses tanggal 11 July 2020.

[WHO22nd-7] World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

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Umeklidinium bromida

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