Seforanida
 | |
| Data klinis | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| Rute pemberian | Intramuskular |
| Kode ATC | |
| Data farmakokinetika | |
| Pengikatan protein | 80,6% |
| Metabolisme | - |
| Waktu paruh eliminasi | 2,6 - 2,98 jam |
| Ekskresi | Ginjal |
| Pengenal | |
| |
| Nomor CAS | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| NIAID ChemDB | |
| CompTox Dashboard (EPA) | |
| Data sifat kimia dan fisik | |
| Rumus | C20H21N7O6S2 |
| Massa molar | 519,55 g·mol−1 |
| Model 3D (JSmol) | |
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  (what is this?) (verify) | |
Seforanida merupakan salah satu antibiotik sefalosporin generasi kedua.[1][2][3] Seforanida mengandung 20 atom karbon dan memiliki massa molekul relatif sebesar 519,554 Da.[4][5][6][7][8][9]
Karakteristik
| Karakteristik | Nilai |
|---|---|
| Jumlah akseptor hidrogen | 12 |
| Jumlah donor hidrogen | 4 |
| Jumlah ikatan rotasi | 10 |
| Koefisien partisi[10] (-{ALogP)}- | -3,2 |
| Kelarutan[11] (-{logS, log(mol/L}-)) | -3,9 |
| Permukaan kutub[12] (-{PSA}-, Å2) | 244,2 |
Referensi
- ^ Crowle A, Sbarbaro J, May M (1988). "Effects of isoniazid and of ceforanide against virulent tubercle bacilli in cultured human macrophages". Tubercle. 69 (1): 15–25. doi:10.1016/0041-3879(88)90036-0. PMID 3140456.
- ^ Campoli-Richards D, Lackner T, Monk J (1987). "Ceforanide. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy". Drugs. 34 (4): 411–37. doi:10.2165/00003495-198734040-00001. PMID 3315624. S2CID 242440792.
- ^ Cone L, Barton S, Woodard D (1987). "Treatment of scleroma with ceforanide". Arch Otolaryngol Head Neck Surg. 113 (4): 374–6. doi:10.1001/archotol.1987.01860040036012. PMID 3814386.
- ^ Crowle AJ, Sbarbaro JA, May MH: Effects of isoniazid and of ceforanide against virulent tubercle bacilli in cultured human macrophages. Tubercle. 1988 Mar;69(1):15-25. PMID 3140456
- ^ Campoli-Richards DM, Lackner TE, Monk JP: Ceforanide. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. Drugs. 1987 Oct;34(4):411-37. PMID 3315624
- ^ Cone LA, Barton SM, Woodard DR: Treatment of scleroma with ceforanide. Arch Otolaryngol Head Neck Surg. 1987 Apr;113(4):374-6. PMID 3814386
- ^ Barriere SL, Mills J: Ceforanide: antibacterial activity, pharmacology, and clinical efficacy. Pharmacotherapy. 1982 Nov-Dec;2(6):322-7. PMID 6762529
- ^ PMID 21059682 (PMID 21059682)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ^ PMID 18048412 (PMID 18048412)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). "Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods". The Journal of Physical Chemistry A. 102 (21): 3762–3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
- ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). "Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices". Journal of Chemical Information and Computer Sciences. 41 (6): 1488–1493. doi:10.1021/ci000392t. PMID 11749573.
- ^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). "Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties". Journal of Medicinal Chemistry. 43 (20): 3714–3717. doi:10.1021/jm000942e. PMID 11020286.
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