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Perfenazin
Data klinis
AHFS/Drugs.com	monograph
MedlinePlus	a682165
Kategori; kehamilan	AU: C ; ;
Rute; pemberian	Oral dan intramuskular
Kelas obat	Antipsikotik tipikal
Kode ATC	N05AB03 (WHO) ;
Status hukum
Status hukum	UK: POM (Hanya resep) ; US: ℞-only ;
Data farmakokinetika
Bioavailabilitas	40%
Metabolisme	hati
Waktu paruh eliminasi	8–12 (hingga 20) jam
Pengenal
	Nama IUPAC 2-[4-[3-(2-kloro-10H-fenotiazin-10-il) propil]piperazin-1-il]etanol;
Nomor CAS	58-39-9 ;
PubChem CID	4748;
IUPHAR/BPS	209;
DrugBank	DB00850 ;
ChemSpider	4586 ;
UNII	FTA7XXY4EZ;
KEGG	D00503 ;
ChEBI	CHEBI:8028 ;
ChEMBL	ChEMBL567 ;
CompTox Dashboard (EPA)	DTXSID1023441 ;
ECHA InfoCard	100.000.346
Data sifat kimia dan fisik
Rumus	C21H26ClN3OS
Massa molar	403,97 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
	SMILES Clc2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(CCO)CC4;
	InChI InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2 ; Key:RGCVKNLCSQQDEP-UHFFFAOYSA-N ;
	(verify)

Perfenazin adalah suatu obat antipsikotik tipikal. Secara kimia, obat ini diklasifikasikan sebagai piperazinil fenotiazina. Awalnya dipasarkan di Amerika Serikat dengan nama Trilafon. Obat ini telah digunakan secara klinis selama beberapa dekade.

Perfenazin kira-kira sepuluh kali lebih poten daripada klorpromazin pada reseptor dopamin-2 (D2);^[2] sehingga perfenazin dianggap sebagai antipsikotik dengan potensi sedang.^[3]^[4]

Referensi

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (dalam bahasa Brazilian Portuguese). Diário Oficial da União (dipublikasikan 2023-04-04). Diarsipkan dari versi aslinya tanggal 2023-08-03. Diakses tanggal 2023-08-16.
^ Rees L (August 1960). "Chlorpromazine and allied phenothiazine derivatives". British Medical Journal. 2 (5197): 522–5. doi:10.1136/bmj.2.5197.522. PMC 2097091. PMID 14436902.
^ Ascher-Svanum H, Zhu B, Faries D, Landbloom R, Swartz M, Swanson J (February 2006). "Time to discontinuation of atypical versus typical antipsychotics in the naturalistic treatment of schizophrenia". BMC Psychiatry. 6 8. doi:10.1186/1471-244X-6-8. PMC 1402287. PMID 16504026.
^ Freudenreich O (2007). "Treatment of psychotic disorders". Psychotic disorders. Practical Guides in Psychiatry. Lippincott Williams & Wilkins. hlm. 88. ISBN 978-0-7817-8543-3. Diakses tanggal 2009-06-22.

[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (dalam bahasa Brazilian Portuguese). Diário Oficial da União (dipublikasikan 2023-04-04). Diarsipkan dari versi aslinya tanggal 2023-08-03. Diakses tanggal 2023-08-16.

[2] Rees L (August 1960). "Chlorpromazine and allied phenothiazine derivatives". British Medical Journal. 2 (5197): 522–5. doi:10.1136/bmj.2.5197.522. PMC 2097091. PMID 14436902.

[3] Ascher-Svanum H, Zhu B, Faries D, Landbloom R, Swartz M, Swanson J (February 2006). "Time to discontinuation of atypical versus typical antipsychotics in the naturalistic treatment of schizophrenia". BMC Psychiatry. 6 8. doi:10.1186/1471-244X-6-8. PMC 1402287. PMID 16504026.

[Freu-4] Freudenreich O (2007). "Treatment of psychotic disorders". Psychotic disorders. Practical Guides in Psychiatry. Lippincott Williams & Wilkins. hlm. 88. ISBN 978-0-7817-8543-3. Diakses tanggal 2009-06-22.

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