Ensiklopedia Dunia

Imipramin
Data klinis
Nama dagang	Tofranil, Tofranil-PM, dll
Nama lain	Melipramin; G-22355
AHFS/Drugs.com	monograph
MedlinePlus	a682389
License data	US DailyMed: Imipramine;
Kategori; kehamilan	AU: C ; ;
Rute; pemberian	Oral, injeksi intramuskular
Kode ATC	N06AA02 (WHO) ;
Status hukum
Status hukum	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Hanya resep) ; US: ℞-only ;
Data farmakokinetika
Bioavailabilitas	94–96%
Pengikatan protein	86%
Metabolisme	Hati (CYP1A2, CYP2C19, CYP2D6)
Metabolit	Desipramin
Waktu paruh eliminasi	20 jam
Ekskresi	Ginjal (80%), feses (20%)
Pengenal
	Nama IUPAC 3-(10,11-dihidro-5H-dibenzo[b,f]azepin-5-il)-N,N-dimetilpropan-1-amina;
Nomor CAS	50-49-7 ;
PubChem CID	3696;
IUPHAR/BPS	357;
DrugBank	DB00458 ;
ChemSpider	3568 ;
UNII	OGG85SX4E4;
KEGG	D08070 ; as HCl: D00815 ;
ChEBI	CHEBI:47499 ;
ChEMBL	ChEMBL11 ;
Ligan PDB	IXX (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID1043881 ;
ECHA InfoCard	100.000.039
Data sifat kimia dan fisik
Rumus	C19H24N2
Massa molar	280,42 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
	SMILES CN(C)CCCN1c2ccccc2CCc2ccccc21;
	InChI InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 ; Key:BCGWQEUPMDMJNV-UHFFFAOYSA-N ;
	(verify)

Imipramin merupakan antidepresan trisiklik (TCA) yang terutama digunakan dalam pengobatan depresi. Obat ini juga efektif dalam mengobati kecemasan dan gangguan panik. Obat ini diminum.

Efek samping umumnya meliputi mulut kering, kantuk, pusing, tekanan darah rendah, denyut jantung cepat, retensi urin, dan perubahan elektrokardiogram. Overdosis obat dapat mengakibatkan kematian. Imipramin tampaknya bekerja dengan meningkatkan kadar serotonin dan norepinefrin dan dengan memblokir reseptor serotonin, adrenergik, histamin, dan kolinergik tertentu.

Terlepas dari peringatannya, imipramin tetap penting dalam psikofarmakologi dan pediatri (misalnya, dengan enuresis anak-anak).^[5]^[6]

Referensi

^ "Imipramine Use During Pregnancy". Drugs.com. 28 August 2019. Diakses tanggal 7 February 2020.
^ Heck HA, Buttrill SE, Flynn NW, Dyer RL, Anbar M, Cairns T, Dighe S, Cabana BE (June 1979). "Bioavailability of imipramine tablets relative to a stable isotope-labeled internal standard: increasing the power of bioavailability tests". Journal of Pharmacokinetics and Biopharmaceutics. 7 (3): 233–248. doi:10.1007/BF01060015. PMID 480146. S2CID 23232584.
^ ^a ^b ^c ^d ^e "Product Information Tolerade (imipramine hydrochloride)". TGA eBusiness Services. PMIP Pty Ltd. 4 June 2013. Diarsipkan dari asli tanggal 10 December 2019. Diakses tanggal 16 October 2013.
^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (dalam bahasa Brazilian Portuguese). Diário Oficial da União (dipublikasikan 2023-04-04). Diarsipkan dari versi aslinya tanggal 2023-08-03. Diakses tanggal 2023-08-16.
^ Michelson LK, Marchione K (February 1991). "Behavioral, cognitive, and pharmacological treatments of panic disorder with agoraphobia: critique and synthesis". Journal of Consulting and Clinical Psychology. 59 (1): 100–14. doi:10.1037/0022-006x.59.1.100. PMID 2002125.
^ Schwartz TL, Nihalani N, Simionescu M, Hopkins G (2005). "History repeats itself: pharmacodynamic trends in the treatment of anxiety disorders". Current Pharmaceutical Design. 11 (2): 255–63. doi:10.2174/1381612053382214. PMID 15638761.

Bacaan lebih lanjut

Dean L (2017). "Imipramine Therapy and CYP2D6 and CYP2C19 Genotype". Dalam Pratt VM, McLeod HL, Rubinstein WS, Scott SA, Dean LC, Kattman BL, et al. (ed.). Medical Genetics Summaries. National Center for Biotechnology Information (NCBI). PMID 28520379. Bookshelf ID: NBK425164.

[Drugs.com_pregnancy-1] "Imipramine Use During Pregnancy". Drugs.com. 28 August 2019. Diakses tanggal 7 February 2020.

[Pharm-2] Heck HA, Buttrill SE, Flynn NW, Dyer RL, Anbar M, Cairns T, Dighe S, Cabana BE (June 1979). "Bioavailability of imipramine tablets relative to a stable isotope-labeled internal standard: increasing the power of bioavailability tests". Journal of Pharmacokinetics and Biopharmaceutics. 7 (3): 233–248. doi:10.1007/BF01060015. PMID 480146. S2CID 23232584.

[Tolerade-3] "Product Information Tolerade (imipramine hydrochloride)". TGA eBusiness Services. PMIP Pty Ltd. 4 June 2013. Diarsipkan dari asli tanggal 10 December 2019. Diakses tanggal 16 October 2013.

[4] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (dalam bahasa Brazilian Portuguese). Diário Oficial da União (dipublikasikan 2023-04-04). Diarsipkan dari versi aslinya tanggal 2023-08-03. Diakses tanggal 2023-08-16.

[pmid2002125-5] Michelson LK, Marchione K (February 1991). "Behavioral, cognitive, and pharmacological treatments of panic disorder with agoraphobia: critique and synthesis". Journal of Consulting and Clinical Psychology. 59 (1): 100–14. doi:10.1037/0022-006x.59.1.100. PMID 2002125.

[pmid15638761-6] Schwartz TL, Nihalani N, Simionescu M, Hopkins G (2005). "History repeats itself: pharmacodynamic trends in the treatment of anxiety disorders". Current Pharmaceutical Design. 11 (2): 255–63. doi:10.2174/1381612053382214. PMID 15638761.

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Ensiklopedia Dunia

Imipramin

Referensi

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