Ensiklopedia Dunia

Haloperidol dekanoat
Data klinis
Nama dagang	Halomonth, Haldol Decanoate, Haldol Decanoas, Haloperidol Decanoat, Neoperidole, Serenase Dekanoat
Nama lain	KD-136; R-13672
Rute; pemberian	Injeksi intramuskular
Kelas obat	Typical antipsychotic
Status hukum
Status hukum	US: ℞-only ;
Pengenal
	Nama IUPAC [4-(4-klorofenil)-1-[4-(4-fluorofenil)-4-oksobutil]piperidin-4-il] dekanoat;
Nomor CAS	74050-97-8 ; 77129-05-6;
PubChem CID	52919;
DrugBank	DBSALT001195;
ChemSpider	47814;
UNII	AC20PJ4101;
KEGG	D01898;
ChEBI	CHEBI:31664;
ChEMBL	ChEMBL1200986;
CompTox Dashboard (EPA)	DTXSID50224951 ;
ECHA InfoCard	100.070.597
Data sifat kimia dan fisik
Rumus	C31H41ClFNO3
Massa molar	530,12 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
	SMILES CCCCCCCCCC(=O)OC1(CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F)C3=CC=C(C=C3)Cl;
	InChI InChI=1S/C31H41ClFNO3/c1-2-3-4-5-6-7-8-11-30(36)37-31(26-14-16-27(32)17-15-26)20-23-34(24-21-31)22-9-10-29(35)25-12-18-28(33)19-13-25/h12-19H,2-11,20-24H2,1H3; Key:GUTXTARXLVFHDK-UHFFFAOYSA-N;

Haloperidol dekanoat adalah antipsikotik tipikal yang digunakan dalam pengobatan skizofrenia.^[1]^[2]^[3]^[4] Obat ini diberikan melalui suntikan ke otot dengan dosis 100 hingga 200 mg sekali setiap 4 minggu atau bulanan.^[5]^[6]^[7] Situs dorsogluteal direkomendasikan. Jarum 3,75 cm (1,5 inci), ukuran 21 umumnya digunakan, tetapi individu yang mengalami obesitas mungkin memerlukan jarum 6,5 cm (2,5 inci) untuk memastikan bahwa obat ini benar-benar disuntikkan secara intramuskular dan bukan subkutan. Haloperidol dekanoat tersedia dalam bentuk larutan minyak wijen dan benzil alkohol 50 atau 100 mg/mL dalam ampoule atau alat suntik yang sudah diisi sebelumnya.^[5]^[6]^[8] Waktu paruh eliminasinya setelah beberapa dosis adalah 21 hari.^[9]^[10] Obat ini dipasarkan di banyak negara di seluruh dunia.^[2]^[11]

Referensi

^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. hlm. 619–. ISBN 978-1-4757-2085-3.
^ ^a ^b Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. hlm. 509–. ISBN 978-3-88763-075-1.
^ Kleemann A, Engel J, Kutscher B, Reichert D (2009). "Haloperidol decanoate". Pharmaceutical Substances: Syntheses, Patents and Applications of the most relevant APIs (Edisi 5th). Thieme. hlm. 1376–. ISBN 978-3-13-179525-0.
^ Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. hlm. 139–. ISBN 978-94-011-4439-1.
^ ^a ^b Pagliaro LA, Pagliaro AM (1999). Psychologists' Psychotropic Drug Reference. Psychology Press. hlm. 260–. ISBN 978-0-87630-964-3.
^ ^a ^b Wyatt RJ, Chew RH (20 May 2008). Wyatt's Practical Psychiatric Practice: Forms and Protocols for Clinical Use. American Psychiatric Pub. hlm. 142–. ISBN 978-1-58562-687-8.
^ Fortinash KM, Worret PA (13 June 2014). Psychiatric Mental Health Nursing - E-Book. Elsevier Health Sciences. hlm. 572–. ISBN 978-0-323-29327-3.
^ Lee M, Desai A (2007). Gibaldi's Drug Delivery Systems in Pharmaceutical Care. ASHP. hlm. 281–. ISBN 978-1-58528-136-7.
^ Davis JM, Matalon L, Watanabe MD, Blake L, Metalon L (May 1994). "Depot antipsychotic drugs. Place in therapy". Drugs. 47 (5): 741–773. doi:10.2165/00003495-199447050-00004. PMID 7520856. S2CID 46962898.
^ Zuidema J, Pieters FA, Duchateau GS (1988). "Release and absorption rate aspects of intramuscularly injected pharmaceuticals". International Journal of Pharmaceutics. 47 (1–3): 1–12. doi:10.1016/0378-5173(88)90209-8. ISSN 0378-5173.
^ "Haloperidol Uses, Side Effects & Warnings".

[Elks2014-1] Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. hlm. 619–. ISBN 978-1-4757-2085-3.

[IndexNominum2000-2] Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. hlm. 509–. ISBN 978-3-88763-075-1.

[KleemannEngel2014-3] Kleemann A, Engel J, Kutscher B, Reichert D (2009). "Haloperidol decanoate". Pharmaceutical Substances: Syntheses, Patents and Applications of the most relevant APIs (Edisi 5th). Thieme. hlm. 1376–. ISBN 978-3-13-179525-0.

[MortonHall2012-4] Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. hlm. 139–. ISBN 978-94-011-4439-1.

[PagliaroPagliaro1999-5] Pagliaro LA, Pagliaro AM (1999). Psychologists' Psychotropic Drug Reference. Psychology Press. hlm. 260–. ISBN 978-0-87630-964-3.

[WyattChew2008-6] Wyatt RJ, Chew RH (20 May 2008). Wyatt's Practical Psychiatric Practice: Forms and Protocols for Clinical Use. American Psychiatric Pub. hlm. 142–. ISBN 978-1-58562-687-8.

[FortinashWorret2014-7] Fortinash KM, Worret PA (13 June 2014). Psychiatric Mental Health Nursing - E-Book. Elsevier Health Sciences. hlm. 572–. ISBN 978-0-323-29327-3.

[LeeDesai2007-8] Lee M, Desai A (2007). Gibaldi's Drug Delivery Systems in Pharmaceutical Care. ASHP. hlm. 281–. ISBN 978-1-58528-136-7.

[pmid7520856-9] Davis JM, Matalon L, Watanabe MD, Blake L, Metalon L (May 1994). "Depot antipsychotic drugs. Place in therapy". Drugs. 47 (5): 741–773. doi:10.2165/00003495-199447050-00004. PMID 7520856. S2CID 46962898.

[ZuidemaPieters1988-10] Zuidema J, Pieters FA, Duchateau GS (1988). "Release and absorption rate aspects of intramuscularly injected pharmaceuticals". International Journal of Pharmaceutics. 47 (1–3): 1–12. doi:10.1016/0378-5173(88)90209-8. ISSN 0378-5173.

[Drugs.com-11] "Haloperidol Uses, Side Effects & Warnings".

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Haloperidol dekanoat

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