Ensiklopedia Dunia

GPR123
Pengidentifikasi
Alias	ADGRA1, GPR123, adhesion G protein-coupled receptor A1
ID Eksternal	OMIM: 612302; MGI: 1277167; HomoloGene: 18582; GeneCards: ADGRA1; OMA:ADGRA1 - orthologs
Pola ekspresi RNA
	Ekspresi tertinggi di
	right frontal lobe; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; Korteks prefrontal; ; Hipotalamus; ; lateral nuclear group of thalamus; ; primary visual cortex; ; Amigdala; ; ventricular zone;
	Ekspresi tertinggi di
	facial motor nucleus; ; lumbar subsegment of spinal cord; ; medial dorsal nucleus; ; Rostral migratory stream; ; substantia nigra; ; lateral geniculate nucleus; ; medial geniculate nucleus; ; subiculum; ; dentate gyrus of hippocampal formation granule cell; ; Amigdala;
	Referensi data ekspresi selengkapnya
	n/a
Ontologi gen
Fungsi molekuler	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Komponen seluler	komponen integral membran; membran; postsynaptic density; glutamatergic synapse;
Proses biologis	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; signal transduction;
	Sumber:Amigo / QuickGO
Ortologi
	84435
	52389
	ENSG00000197177
	ENSMUSG00000025475
	Q86SQ6
	Q8C4G9
	NM_001083909; NM_001291085; NM_032422
	NM_177469
	NP_001077378; NP_001278014
	NP_803420
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

GPR123 (nama resmi: ADGRA1) adalah protein pada manusia disandi oleh gen GPR123.^[3]^[4] GPR123 adalah anggota dari keluarga reseptor GPCR adhesi. Anggota keluarga biasanya ditandai dengan daerah ekstraseluler diperpanjang dengan sejumlah variabel domain protein digabungkan ke domain TM7 melalui domain dikenal sebagai domain GAIN (GPCR-Autoproteolysis INducing).^[5]^[6]^[7]

Referensi

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (Feb 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun. 301 (3): 725–34. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.
^ "Entrez Gene: GPR123 G protein-coupled receptor 123". Diarsipkan dari asli tanggal 2023-07-26.
^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.
^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.
^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12565841-3] Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (Feb 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun. 301 (3): 725–34. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.

[entrez-4] "Entrez Gene: GPR123 G protein-coupled receptor 123". Diarsipkan dari asli tanggal 2023-07-26.

[isbn1-4419-7912-3-5] Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.

[pmid12435584-6] Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.

[pmid22333914-7] Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Ensiklopedia Dunia

GPR123

Referensi

Beranda

Program Studi