Ensiklopedia Dunia

Ergolina
Data klinis
Kode ATC	none;
Pengenal
	Nama IUPAC (6aR)-4,6,6a,7,8,9,10,10a-Oktahidroindolo[4,3-fg]kuinolina;
Nomor CAS	478-88-6 ;
PubChem CID	6857537;
ChemSpider	5256873 ;
UNII	D5RC6H62GW;
ChEBI	CHEBI:38484 ;
CompTox Dashboard (EPA)	DTXSID00963944 ;
Data sifat kimia dan fisik
Rumus	C14H16N2
Massa molar	212,30 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
	SMILES [H][C@@]34Cc1c[nH]c2cccc(c12)[C@@]3([H])CCCN4;
	InChI InChI=1S/C14H16N2/c1-3-11-10-4-2-6-15-13(10)7-9-8-16-12(5-1)14(9)11/h1,3,5,8,10,13,15-16H,2,4,6-7H2/t10-,13-/m1/s1 ; Key:RHGUXDUPXYFCTE-ZWNOBZJWSA-N ;
	(verify)

Ergolina merupakan struktur inti dalam banyak alkaloid dan turunan sintetisnya. Alkaloid ergolina pertama kali dikarakterisasi dalam ergot. Beberapa di antaranya terlibat dalam kondisi ergotisme, yang dapat berupa bentuk kejang^[1] atau bentuk gangren. Meskipun demikian, banyak alkaloid ergolina telah ditemukan bermanfaat secara klinis. Produksi tahunan alkaloid ergot di dunia diperkirakan mencapai 5.000–8.000 kg untuk semua ergopeptin, dan 10.000–15.000 kg untuk asam lisergat, yang terutama digunakan dalam pembuatan turunan semisintetis.^[2]

Zat lain seperti asam lisergat dietilamida (lebih dikenal sebagai LSD), turunan semisintesis; dan ergina, turunan alami yang ditemukan di Argyreia nervosa, Ipomoea tricolor, dan spesies terkait; dikenal sebagai zat psikedelik.^[3]

Referensi

^ Schardl CL, Panaccione DG, Tudzynski P (2006). "Ergot alkaloids--biology and molecular biology". The Alkaloids. Chemistry and Biology. 63. Elsevier: 45–86. doi:10.1016/s1099-4831(06)63002-2. ISBN 978-0-12-469563-4. PMID 17133714.
"Clavines are thought to contribute substantially to convulsive ergotism, since C. fusiformis ergots, which possess clavines, but no [lysergic acid] or lysergyl amides, cause convulsive symptoms (26). However, the ergopeptines are known to produce similar symptoms, and are also thought to cause gangrenous ergotism (6). The occurrence of convulsive ergotism without dry gangrene suggests that other clavine or lysergyl alkaloids are involved, or that individual effects of speciﬁc ergopeptines may give clinically different syndromes (6)."
II. Through the Ages: A History of Ergot Alkaloid Use, Abuse, and Poisoning, p. 50
^ Schiff PL (October 2006). "Ergot and its alkaloids". American Journal of Pharmaceutical Education. 70 (5): 98. doi:10.5688/aj700598 (tidak aktif 1 July 2025). PMC 1637017. PMID 17149427. Pemeliharaan CS1: DOI nonaktif per Juli 2025 (link)
^ Juszczak GR, Swiergiel AH (2013). "Recreational use of D-lysergamide from the seeds of Argyreia nervosa, Ipomoea tricolor, Ipomoea violacea, and Ipomoea purpurea in Poland". Journal of Psychoactive Drugs. 45 (1): 79–93. doi:10.1080/02791072.2013.763570. PMID 23662334. S2CID 22086799.

Pranala luar

[1] Schardl CL, Panaccione DG, Tudzynski P (2006). "Ergot alkaloids--biology and molecular biology". The Alkaloids. Chemistry and Biology. 63. Elsevier: 45–86. doi:10.1016/s1099-4831(06)63002-2. ISBN 978-0-12-469563-4. PMID 17133714.
"Clavines are thought to contribute substantially to convulsive ergotism, since C. fusiformis ergots, which possess clavines, but no [lysergic acid] or lysergyl amides, cause convulsive symptoms (26). However, the ergopeptines are known to produce similar symptoms, and are also thought to cause gangrenous ergotism (6). The occurrence of convulsive ergotism without dry gangrene suggests that other clavine or lysergyl alkaloids are involved, or that individual effects of speciﬁc ergopeptines may give clinically different syndromes (6)."
II. Through the Ages: A History of Ergot Alkaloid Use, Abuse, and Poisoning, p. 50

[:02-2] Schiff PL (October 2006). "Ergot and its alkaloids". American Journal of Pharmaceutical Education. 70 (5): 98. doi:10.5688/aj700598 (tidak aktif 1 July 2025). PMC 1637017. PMID 17149427. Pemeliharaan CS1: DOI nonaktif per Juli 2025 (link)

[3] Juszczak GR, Swiergiel AH (2013). "Recreational use of D-lysergamide from the seeds of Argyreia nervosa, Ipomoea tricolor, Ipomoea violacea, and Ipomoea purpurea in Poland". Journal of Psychoactive Drugs. 45 (1): 79–93. doi:10.1080/02791072.2013.763570. PMID 23662334. S2CID 22086799.

[1]

[2]

[3]

Ensiklopedia Dunia

Ergolina

Referensi

Pranala luar

Beranda

Program Studi

Data klinis


Kode ATC	none
Pengenal
Nama IUPAC (6aR)-4,6,6a,7,8,9,10,10a-Oktahidroindolo[4,3-fg]kuinolina
Nomor CAS	478-88-6^Y
PubChem CID	6857537
ChemSpider	5256873^Y
UNII	D5RC6H62GW
ChEBI	CHEBI:38484^Y
CompTox Dashboard (EPA)	DTXSID00963944
Data sifat kimia dan fisik
Rumus	C₁₄H₁₆N₂
Massa molar	212,30 g·mol⁻¹
Model 3D (JSmol)	Gambar interaktif
SMILES [H][C@@]34Cc1c[nH]c2cccc(c12)[C@@]3([H])CCCN4
InChI InChI=1S/C14H16N2/c1-3-11-10-4-2-6-15-13(10)7-9-8-16-12(5-1)14(9)11/h1,3,5,8,10,13,15-16H,2,4,6-7H2/t10-,13-/m1/s1^Y Key:RHGUXDUPXYFCTE-ZWNOBZJWSA-N^Y
(verify)