Ensiklopedia Dunia

Amiodaron
Data klinis
Pengucapan	/ˌæmiˈoʊdəroʊn/ or /əˈmiːoʊdəˌroʊn/
Nama dagang	Cordarone, Kendaron, Nexterone, Pacerone, Tiaryt, dll
AHFS/Drugs.com	monograph
MedlinePlus	a687009
License data	US DailyMed: Amiodarone;
Kategori; kehamilan	AU: C ; ;
Rute; pemberian	Oral, intravena, intraoseus
Kode ATC	C01BD01 (WHO) ;
Status hukum
Status hukum	AU: S4 (Prescription only) ; CA: ℞-only ; US: ℞-only ;
Data farmakokinetika
Bioavailabilitas	20–55%
Pengikatan protein	96%
Metabolisme	Hati
Waktu paruh eliminasi	58 hari (kisaran 15–142 hari)
Ekskresi	Terutama hati dan empedu
Pengenal
	Nama IUPAC (2-{4-[(2-butil-1-benzofuran-3-il)karbonil]-2,6-diiodofenoksi}etil)dietilamina;
Nomor CAS	1951-25-3 ;
PubChem CID	2157;
IUPHAR/BPS	2566;
DrugBank	DB01118 ;
ChemSpider	2072 ;
UNII	N3RQ532IUT;
KEGG	D02910 ;
ChEBI	CHEBI:2663 ;
ChEMBL	ChEMBL633 ;
CompTox Dashboard (EPA)	DTXSID7022592 ;
ECHA InfoCard	100.016.157
Data sifat kimia dan fisik
Rumus	C25H29I2NO3
Massa molar	645,32 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
	SMILES CCN(CC)CCOc1c(I)cc(cc1I)C(=O)c2c3ccccc3oc2CCCC;
	InChI InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3 ; Key:IYIKLHRQXLHMJQ-UHFFFAOYSA-N ;
	(verify)

Amiodaron adalah obat antiaritmia, Badan Pengawas Obat dan Makanan Amerika Serikat (FDA), telah memberi label amiodaron untuk pengobatan aritmia ventrikel yang mengancam jiwa, obat ini umumnya digunakan di luar label untuk mengobati takiaritmia supraventrikular seperti fibrilasi atrium serta untuk pencegahan takiaritmia ventrikel (VT) pada risiko tinggi pasien.^[4]^[5]^[6]

Referensi

^ "Pacerone- amiodarone hydrochloride tablet". DailyMed. Diakses tanggal 8 September 2021.
^ "Cordarone (amiodarone) tablets, for oral use Initial U.S. Approval: 1985". DailyMed. 30 Oktober 2018. Diakses tanggal 8 September 2021.
^ "Nexterone- Amiodarone HCl injection, solution". DailyMed. Diakses tanggal 8 September 2021.
^ Voulgareli, Ilektra; Chronaiou, Alexandra; Tsoukalas, Dionisios; Tsoukalas, George (2018-12). "A rare case of lipoid pneumonia attributed to amiodarone". Pneumonia. 10 (1). doi:10.1186/s41479-018-0056-3. ISSN 2200-6133. Pemeliharaan CS1: DOI bebas tanpa ditandai (link)
^ Soar, Jasmeet; Perkins, Gavin D.; Maconochie, Ian; Böttiger, Bernd W.; Deakin, Charles D.; Sandroni, Claudio; Olasveengen, Theresa M.; Wyllie, Jonathan; Greif, Robert (2019-01). "European Resuscitation Council Guidelines for Resuscitation: 2018 Update – Antiarrhythmic drugs for cardiac arrest". Resuscitation. 134: 99–103. doi:10.1016/j.resuscitation.2018.11.018. ISSN 0300-9572.
^ Serhan Özcan, Kazım; Zengin, Ahmet; Tatlısu, Adem; Aruğarslan, Emre; Nurkalem, Zekeriya (2014-02). "Anaphylactic shock associated with intravenous amiodarone". Journal of Cardiology Cases. 9 (2): 61–62. doi:10.1016/j.jccase.2013.10.001. ISSN 1878-5409.

Artikel bertopik farmasi ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[Pacerone_FDA_label-1] "Pacerone- amiodarone hydrochloride tablet". DailyMed. Diakses tanggal 8 September 2021.

[Cordarone_FDA_label-2] "Cordarone (amiodarone) tablets, for oral use Initial U.S. Approval: 1985". DailyMed. 30 Oktober 2018. Diakses tanggal 8 September 2021.

[Nexterone_FDA_label-3] "Nexterone- Amiodarone HCl injection, solution". DailyMed. Diakses tanggal 8 September 2021.

[4] Voulgareli, Ilektra; Chronaiou, Alexandra; Tsoukalas, Dionisios; Tsoukalas, George (2018-12). "A rare case of lipoid pneumonia attributed to amiodarone". Pneumonia. 10 (1). doi:10.1186/s41479-018-0056-3. ISSN 2200-6133. Pemeliharaan CS1: DOI bebas tanpa ditandai (link)

[5] Soar, Jasmeet; Perkins, Gavin D.; Maconochie, Ian; Böttiger, Bernd W.; Deakin, Charles D.; Sandroni, Claudio; Olasveengen, Theresa M.; Wyllie, Jonathan; Greif, Robert (2019-01). "European Resuscitation Council Guidelines for Resuscitation: 2018 Update – Antiarrhythmic drugs for cardiac arrest". Resuscitation. 134: 99–103. doi:10.1016/j.resuscitation.2018.11.018. ISSN 0300-9572.

[6] Serhan Özcan, Kazım; Zengin, Ahmet; Tatlısu, Adem; Aruğarslan, Emre; Nurkalem, Zekeriya (2014-02). "Anaphylactic shock associated with intravenous amiodarone". Journal of Cardiology Cases. 9 (2): 61–62. doi:10.1016/j.jccase.2013.10.001. ISSN 1878-5409.

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Amiodaron

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