Ensiklopedia Dunia

Alprenolol
Data klinis
AHFS/Drugs.com	International Drug Names
Rute; pemberian	Oral
Kode ATC	C07AA01 (WHO) ;
Data farmakokinetika
Pengikatan protein	80% - 90%
Waktu paruh eliminasi	2-3 jam → 4-OH-alprenolol
Pengenal
	Nama IUPAC (RS)-1-(2-alilfenoksi)-3-(isopropilamino)propan-2-ol;
Nomor CAS	13655-52-2 ;
PubChem CID	2119;
IUPHAR/BPS	563;
DrugBank	DB00866 ;
ChemSpider	2035 ;
UNII	877K5MQ27W;
KEGG	D07156 ;
ChEBI	CHEBI:51211 ;
ChEMBL	ChEMBL266195 ;
CompTox Dashboard (EPA)	DTXSID0045127 ;
ECHA InfoCard	100.033.750
Data sifat kimia dan fisik
Rumus	C15H23NO2
Massa molar	249,35 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
	SMILES O(c1ccccc1C\C=C)CC(O)CNC(C)C;
	InChI InChI=1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3 ; Key:PAZJSJFMUHDSTF-UHFFFAOYSA-N ;
	(verify)

Alprenolol atau alfeprol adalah penghalang beta non-selektif serta antagonis reseptor 5-5-HT_1A dan 5-5-HT_1B,^[1] yang digunakan dalam pengobatan angina pektoris.^[2] Obat ini tidak lagi dipasarkan oleh AstraZeneca, tetapi mungkin masih tersedia dari perusahaan farmasi lain atau secara generik.

Referensi

^ Langlois M, Brémont B, Rousselle D, Gaudy F (1993). "Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors". Eur. J. Pharmacol. 244 (1): 77–87. doi:10.1016/0922-4106(93)90061-d. PMID 8093601.
^ Hickie JB (1970). "Alprenolol ("aptin") in angina pectoris. A double-blind multicentre trial". Med. J. Aust. 2 (6): 268–72. doi:10.5694/j.1326-5377.1970.tb49984.x. PMID 4393977. S2CID 6879318.

[pmid8093601-1] Langlois M, Brémont B, Rousselle D, Gaudy F (1993). "Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors". Eur. J. Pharmacol. 244 (1): 77–87. doi:10.1016/0922-4106(93)90061-d. PMID 8093601.

[pmid4393977-2] Hickie JB (1970). "Alprenolol ("aptin") in angina pectoris. A double-blind multicentre trial". Med. J. Aust. 2 (6): 268–72. doi:10.5694/j.1326-5377.1970.tb49984.x. PMID 4393977. S2CID 6879318.

[1]

[2]

Ensiklopedia Dunia

Alprenolol

Referensi

Beranda

Program Studi

Data klinis

AHFS/Drugs.com	International Drug Names
Rute pemberian	Oral
Kode ATC	C07AA01 (WHO)
Data farmakokinetika
Pengikatan protein	80% - 90%
Waktu paruh eliminasi	2-3 jam → 4-OH-alprenolol
Pengenal
Nama IUPAC (RS)-1-(2-alilfenoksi)-3-(isopropilamino)propan-2-ol
Nomor CAS	13655-52-2^Y
PubChem CID	2119
IUPHAR/BPS	563
DrugBank	DB00866^Y
ChemSpider	2035^Y
UNII	877K5MQ27W
KEGG	D07156^Y
ChEBI	CHEBI:51211^Y
ChEMBL	ChEMBL266195^Y
CompTox Dashboard (EPA)	DTXSID0045127
ECHA InfoCard	100.033.750
Data sifat kimia dan fisik
Rumus	C₁₅H₂₃NO₂
Massa molar	249,35 g·mol⁻¹
Model 3D (JSmol)	Gambar interaktif
SMILES O(c1ccccc1C\C=C)CC(O)CNC(C)C
InChI InChI=1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3^Y Key:PAZJSJFMUHDSTF-UHFFFAOYSA-N^Y
(verify)